We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
9
Effectiveness of calcitriol combination therapy
Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study.
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
Most Useful Reviews
10
Bones don't hurt
14 people found this helpful
I ordered this calcium citrate + Vitamin D³ for my pregnancy. As my body needed more calcium, I often experienced bone pain and numbness in my legs at night. However, I am thoroughly convinced that Solgar works wonders. I take one vitamin after breakfast for optimal absorption. The delivery to Moscow was swift, and the jar was securely packed. I appreciate the protective coating under the lid. All the vitamins were intact, and the expiry date is good. I feel fantastic now, my hair is back to normal, and my bones no longer ache!
Read More
7.5
Very satisfied
6 people found this helpful
The best form of calcium is citrate, particularly recommended for older individuals. I follow my doctor's advice and have ordered this product multiple times, always feeling very satisfied. The added vitamin D3 significantly aids in calcium absorption, effectively directing it to my bones.
Read More
9
Alleviated pain
3 people found this helpful
I regularly buy this complex—Calcium with vitamin D3—for my dad. At his age, calcium levels decline. Our doctor recommended it, and it helps significantly. Dad feels great. If earlier his bones hurt, now they don't. An excellent complex for body health.
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
Effectiveness of calcitriol combination therapy
Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study.
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
Vitamin D reduces fracture risk
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
We evaluated the effects of growth hormone therapy on a 12-year-old boy with Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) and found some promising results.
Alongside sodium phosphate and potassium citrate therapy, incorporating recombinant human growth hormone (rhGH) and Fluconazole led to improvements in his chronic bone pain and overall growth over six months.
However, it's important to note that while there was progress, the changes in kidney function remained unclear. Our findings suggest that further studies are necessary to confirm the effectiveness of this approach.
I ordered this calcium citrate + Vitamin D³ for my pregnancy. As my body needed more calcium, I often experienced bone pain and numbness in my legs at night. However, I am thoroughly convinced that Solgar works wonders. I take one vitamin after breakfast for optimal absorption. The delivery to Moscow was swift, and the jar was securely packed. I appreciate the protective coating under the lid. All the vitamins were intact, and the expiry date is good. I feel fantastic now, my hair is back to normal, and my bones no longer ache!
Read More
7.5
Very satisfied
6 people found this helpful
The best form of calcium is citrate, particularly recommended for older individuals. I follow my doctor's advice and have ordered this product multiple times, always feeling very satisfied. The added vitamin D3 significantly aids in calcium absorption, effectively directing it to my bones.
Read More
9
Alleviated pain
3 people found this helpful
I regularly buy this complex—Calcium with vitamin D3—for my dad. At his age, calcium levels decline. Our doctor recommended it, and it helps significantly. Dad feels great. If earlier his bones hurt, now they don't. An excellent complex for body health.
Read More
9
Highly recommended
2 people found this helpful
This is a fantastic supplement containing calcium and vitamin D3. Calcium keeps bones and teeth robust and healthy while supporting the musculoskeletal and nervous systems. Vitamin D3 aids calcium absorption and regulates the immune, cardiovascular, endocrine, and hormonal systems. Highly recommended!
Read More
9
Pain reduction
1 people found this helpful
I had pain in my elbows and knees for a long time, despite trying various treatments. I purchased calcium citrate with D3 after careful consideration. There are 240 pieces in a jar, which lasts long. After three months, the daily pain has significantly receded, and I only experience occasional discomfort.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Calcium citrate is a calcium salt of citric acid, widely used as a dietary supplement to provide an additional source of calcium for individuals who may not get enough of this essential mineral from their diets. It is particularly popular for its enhanced bioavailability, which means that the body can absorb calcium from calcium citrate more effectively than from other forms of calcium, such as calcium carbonate. This supplement is especially beneficial for those with decreased stomach acid, such as older adults, as it does not require acid for absorption.
In addition to aiding in bone health, calcium plays a crucial role in muscle function, nerve transmission, and blood clotting. Typically, calcium citrate is available in tablet and powder forms, making it easy to incorporate into daily routines. It’s important to follow dosing recommendations and possibly consult with a healthcare provider before starting any supplement regimen to ensure it meets individual dietary needs and health objectives.
Calcium citrate is a popular dietary supplement often recommended for bone health, particularly because it offers a form of calcium that is easily absorbed by the body. While calcium plays a crucial role in maintaining bone density and overall skeletal health, it is important to clarify that calcium citrate itself does not directly alleviate bone pain. Instead, it can help prevent conditions such as osteoporosis, which can contribute to bone pain over time. If you’re experiencing bone pain, it may be linked to various issues, including injury, arthritis, or other underlying conditions, and simply taking calcium citrate may not address the root cause.
If bone pain is a concern, it is always advisable to consult with a healthcare professional. They might recommend a more comprehensive approach that includes not just calcium and vitamin D supplementation, but also lifestyle changes and potential medical therapies based on your specific situation. In summary, while calcium citrate can contribute to long-term bone health, it is not a direct treatment for bone pain.
Based on user reviews, the time it takes to see results from taking calcium citrate with Vitamin D3 can vary. Some users reported experiencing noticeable effects quite rapidly, with improvements in bone density and pain relief within just a few days. For instance, one reviewer noted feeling denser bones and lighter joints by the third day of use Read Review. Others have indicated a more extended timeframe for benefits to manifest, such as a user who reported significant pain reduction after three months of daily intake Read Review.
Interestingly, many users, particularly those using it for ongoing health concerns like pregnancy or post-fracture recovery, emphasized that consistent use over several weeks leads to the best results. One user observed that her mother's knee discomfort improved after a month's use Read Review, while another saw excellent healing progress after a period of 1.5 months Read Review. Overall, the consensus seems to suggest that while some may notice quick improvements, others might find it takes a few weeks to three months to fully appreciate the supplement's benefits.
The scientific research indicates that certain supplements and treatments have shown effectiveness in alleviating bone pain under specific conditions. For example, a study on growth hormone therapy noted improvements in chronic bone pain for a patient with Hereditary Hypophosphatemic Rickets after incorporating recombinant human growth hormone (rhGH) alongside other therapies [1]. Additionally, patients undergoing adefovir therapy for chronic hepatitis B experienced significant bone pain relief and regained mobility after stopping the treatment and focusing on phosphate replacement therapy [2].
Vitamin D supplementation emerges as a critical factor in managing bone pain, especially in populations at higher risk, such as postmenopausal women. Research has demonstrated that correcting vitamin D deficiencies before orthopedic surgeries notably improved pain control in patients post-operation [4]. Furthermore, studies have shown that combining calcitriol (a form of vitamin D) with bisphosphonates significantly reduces osteoporotic bone pain in postmenopausal women, suggesting that this combination not only alleviates pain but also supports long-term bone health [5]. Overall, while the evidence is supportive, it indicates there are various factors to consider, and further research may be necessary for broad applications.
Users have reported a range of positive improvements in their symptoms after taking calcium citrate with Vitamin D3. Many have experienced significant relief from bone pain and discomfort. For instance, one user noted that they no longer experienced bone aches and felt overall fantastic, highlighting improvements in hair and overall well-being during pregnancy Read Review. Another individual shared that after three months of consistent use, their chronic pain in elbows and knees had greatly diminished, with only occasional discomfort remaining Read Review.
Furthermore, users have highlighted the role of this supplement in bone health, with older individuals noting improvements in bone density and reduced stiffness Read Review. Some users undertaking recovery post-surgery or fractures reported faster healing times, which they attributed to the supplement's efficacy in aiding bone recovery Read Review. Although individual experiences can vary, a general consensus among users points to noticeable benefits in joint comfort, overall vitality, and bone health.
Users have expressed positive experiences when combining calcium citrate with vitamin D3 with other supplements for managing bone pain. For instance, one user noted that while taking these supplements alongside collagen and magnesium, they observed improvements in their condition after a fracture Read Review. This sentiment echoes throughout the reviews, where individuals highlighted that the synergistic effects of different supplements can enhance overall efficacy, particularly when dealing with bone health and recovery.
Additionally, many users reported that compliant adherence to a comprehensive supplementation plan, including calcium and vitamin D3, contributed significantly to alleviating pain and improving bone density. One user stated how their mother, after taking the supplement in conjunction with other vitamins for preventive measures, saw notable benefits in her bone health Read Review. Overall, the integration of this supplement with others seems to optimize health outcomes, providing an effective strategy for those targeting bone pain relief and improved skeletal strength.
Based on user reviews, it appears that the right dose for Calcium Citrate to alleviate bone pain varies among individuals but tends to be around one to four tablets daily, often recommended with meals for optimal absorption. Many reviewers, such as one user who takes one tablet daily after breakfast, reported significant improvements in their bone health and overall well-being after consistent use (Read Review). Other users mentioned taking higher doses, such as four tablets a day, indicating this might be effective for adults seeking comprehensive bone support (Read Review).
Several reviews highlight the importance of combining calcium with vitamin D3 to enhance absorption and effectiveness in treating bone pain. Users reported noticing improvements in their conditions and overall feelings of well-being within a few weeks of starting the supplementation. For instance, a user taking it for their father's bone pain saw significant relief and improved quality of life after following their doctor's recommendation (Read Review). Overall, the consensus suggests that for effective bone pain management, establishing an appropriate dosage in conjunction with vitamin D3 is beneficial.
9
Bones become denser
1 people found this helpful
I absolutely LOVE this! The jar is cool, and I've noticed the effects already by the third day—my bones feel denser, and my joints are considerably lighter. As someone who engages in sports, I can easily track the effects of this calcium.
9
Pain reduction
1 people found this helpful
I had pain in my elbows and knees for a long time, despite trying various treatments. I purchased calcium citrate with D3 after careful consideration. There are 240 pieces in a jar, which lasts long. After three months, the daily pain has significantly receded, and I only experience occasional discomfort.
9
Improved bone health
Great. With this supplement, I began to feel absolutely healthy, strong and happy. After almost a month, it relieved me of discomfort in my bones, and my hair and nails became stronger. If you want to strengthen and improve your health, I highly recommend this supplement.
9
Prevention success
19 people found this helpful
At 58, I fell and broke my arm and leg. After plaster removal, I began taking calcium citrate with vitamin D3. After 1.5 months, my bones fused well. I continued until the package was finished. I then ordered more and now take it in courses to prevent osteoporosis. Very happy with this supplement!
10
Bones don't hurt
14 people found this helpful
I ordered this calcium citrate + Vitamin D³ for my pregnancy. As my body needed more calcium, I often experienced bone pain and numbness in my legs at night. However, I am thoroughly convinced that Solgar works wonders. I take one vitamin after breakfast for optimal absorption. The delivery to Moscow was swift, and the jar was securely packed. I appreciate the protective coating under the lid. All the vitamins were intact, and the expiry date is good. I feel fantastic now, my hair is back to normal, and my bones no longer ache!
9
Must be working
1 people found this helpful
I buy this for my mother, and she swears by it. Her bone density check-ups have been excellent, so it must be effective!
9
Vitamins are working
3 people found this helpful
I took this complex following an accident where I had fractures. I noticed that my bones healed more rapidly, as evidenced by X-rays. I'm grateful for my surgeon's advice and can attest that the vitamins are effective. I recommend taking them regularly or in courses; calcium and vitamin D certainly help maintain health and alertness.
7.5
Improved condition
29 people found this helpful
The product is decent; citrate is absorbed better than carbonate. I bought it for my sister, who has a broken arm. While taking it with collagen and magnesium, she mentioned her condition has improved. However, the large pills are inconvenient. Next time, we'll purchase a more concentrated dosage. I personally prefer calcium hydroxyapatite.
7.5
Nutrient support
3 people found this helpful
Calcium is an essential mineral that strengthens the body's bones, cartilage, joints, and teeth. It provides a variety of nutrients that restore bone structure and prevent conditions like osteoporosis and osteochondrosis. I bought it for my mum for prevention; she takes two tablets twice daily. A good option for adults.
7.5
Strengthened bones
2 people found this helpful
Perfectly! Calcium is a crucial mineral that fortifies the body's bones, including cartilage, joints, and teeth. It provides various nutrients that enhance bone strength and improve the structure of cartilage and joints. This mineral is widely used in preventing and treating osteoporosis and osteochondrosis. Calcium citrate also benefits the genitourinary system by preventing kidney stones and combating bladder infections. Indication for use: Complex Solgar Calcium Citrate with Vitamin D3: take four tablets a day with meals.
9
Alleviated pain
3 people found this helpful
I regularly buy this complex—Calcium with vitamin D3—for my dad. At his age, calcium levels decline. Our doctor recommended it, and it helps significantly. Dad feels great. If earlier his bones hurt, now they don't. An excellent complex for body health.
We evaluated the effects of growth hormone therapy on a 12-year-old boy with Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) and found some promising results.
Alongside sodium phosphate and potassium citrate therapy, incorporating recombinant human growth hormone (rhGH) and Fluconazole led to improvements in his chronic bone pain and overall growth over six months.
However, it's important to note that while there was progress, the changes in kidney function remained unclear. Our findings suggest that further studies are necessary to confirm the effectiveness of this approach.
7
Bone pain relief after adefovir
Nephrogenic hypophosphatemic osteomalacia during adefovir monotherapy for chronic hepatitis B monoinfection.
We examined a group of five patients undergoing long-term adefovir dipivoxil treatment for chronic hepatitis B.
All patients displayed low phosphate levels and reported difficulties walking, among other issues. After stopping the treatment, we focused on phosphate replacement and potassium-citrate therapy.
Encouragingly, after six months, participants experienced significant relief from bone pain, and some even regained the ability to walk independently.
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Effectiveness of calcitriol combination therapy
Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study.
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
References
Filler G, Schott C, Salerno FR, Ens A, McIntyre CW, et al. Growth hormone therapy in HHRH. Bone Rep. 2022;16:101591. doi:10.1016/j.bonr.2022.101591
Xu Y, Shen P, Pan X, Chen N. Nephrogenic hypophosphatemic osteomalacia during adefovir monotherapy for chronic hepatitis B monoinfection. Clin Kidney J. 2013;6:379. doi:10.1093/ckj/sft069
Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
Han K, Wang X. Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study. Medicine (Baltimore). 2024;103:e40171. doi:10.1097/MD.0000000000040171
von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. doi:10.1093/jbmrpl/ziae139